運動せずに運動不足解消？
News Release from Federation of American Societies for Experimental Biology on February 29, 2012.
(c) flickr & riekhavoc (caught up?)
筋肉量の減少を，病気が原因の場合だけでなく運動不足による場合も防ぐ方法が，動物実験で示唆された。この実験では，健康なマウスと敗血症または癌のあるマウスを用い，筋肉にあるFOXOと呼ばれる転写因子ファミリーの活性を遺伝的に低下させた。すると，敗血症または癌のあるマウスでは筋肉量の減少が顕著に抑制され，しかも健康なマウスでは筋細胞が大きくなっており，タンパク質が合成されたことを示した。癌や重度の感染症で患者の生活の質を改善し，生存率を上げる一方，加齢現象や運動不足による筋肉への影響を軽減することもできる方法が開発されるかもしれない。（吉田素子）
No Workout? No Worries: Scientists Prevent Muscle Loss in Mice, Despite Disease and Inactivity
New research in the FASEB Journal demonstrates that the Forkhead boxO family of transcription factors are key regulators of skeletal muscle mass and inhibition prevents muscle loss
If you want big muscles without working out, there's hope. In the March 2012 print issue of the FASEB Journal, scientists from the University of Florida report that a family of protein transcription factors, called "Forkhead (Fox0)" plays a significant role in the regulation of skeletal muscle mass. Specifically, they found that interfering with the activity of these transcription factors prevents muscle wasting associated with cancer and sepsis, and even promotes muscle growth. This discovery is likely to be relevant to any disease, condition or lifestyle that leads to muscle wasting, including voluntary inactivity.
"The loss of muscle mass is a major contributor to disease-related deaths," said Andrew R. Judge, Ph.D., a researcher involved in the work from the Department of Physical Therapy at the University of Florida in Gainesville. "FoxO proteins may provide a target for therapies aimed at reducing muscle wasting and thus improving the quality of life and survival rates for patients with many different diseases."
To make this discovery, Judge and colleagues genetically inhibited the activity of "Forkhead boxO" proteins, or "FoxO," in the skeletal muscle of healthy control mice, septic mice, and mice with cancer. The loss of muscle mass in those with cancer and sepsis was significantly decreased by inhibition of FoxO activity.
［単語和訳］
Workout：運動 Muscle Loss：筋肉量低下 Mice：マウス Inactivity：運動不足
FASEB：米国実験生物学会連合（Federation of American Societies for Experimental Biologyの略） Forkhead boxO：フォークヘッドボックスO（転写因子のファミリーの名称，略してFoxO） family：ファミリー（類似のタンパク質群を指す） transcription factors：転写因子 regulators：調節因子 skeletal muscle mass：骨格筋量 inhibition：抑制
protein：タンパク質 Specifically：具体的には interfering with：～を阻害すること muscle wasting：筋消耗 cancer：癌 sepsis：敗血症 relevant to：～に関連する voluntary：自発的な
contributor to：～の一因 disease-related：疾患関連の Ph.D.：博士 researcher：研究者 involved in：～に参加した Physical Therapy：理学療法 therapies：治療 aimed at：～を目的とした quality of life：生活の質 survival rates：生存率
colleagues：同僚，研究仲間 genetically：遺伝的に inhibited：～を抑制した activity：活性 control：対照の septic：敗血症の significantly：著しく
